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R&D Story 06
Holistic care to help keep teeth for life
Our body is equipped with the ability to heal injuries naturally. By developing oral care technology that supports this regenerative ability, Sunstar makes it possible for us to retain our teeth and periodontal tissues for life.
Teeth need gums and the alveolar bone
Periodontal tissues such as the gums and alveolar bone provide structural stability to our teeth, and thus play an important role in maintaining oral health.
Insufficient teeth cleaning can damage not only the teeth themselves but also the surrounding tissues – causing plaque made of bacteria to accumulate and trigger gingivitis. When left untreated, the gingivitis transforms into periodontitis, damaging the bone. Eventually when bone loss is severe, the tooth is no longer anchored and falls out.
Stimulating regeneration in periodontal treatments
Periodontitis can severely damage the tissues around the teeth including the bone. However, under certain conditions the alveolar bone can be regenerated or repaired to some degree just as a broken bone heals itself.
At Sunstar, we believe it is important to keep not only the teeth themselves, but also the surrounding tissues healthy — enabling us to retain our natural teeth for life. We are all born with the natural ability to repair and sustain the periodontal tissues after injury.
The treatment technologies developed at Sunstar harness and build on this ability.
– GUIDOR bioresorbable
Sunstar’s GUIDOR bioresorbable matrix barrier (GUIDOR matrix barrier) an artificial membrane that aids the regeneration of the alveolar bone and periodontal ligament.
Gingival tissues grow much faster than bone and invade the space necessary for the bone to regenerate. Therefore, to secure space for bone regeneration, GUIDOR matrix barrier is inserted between the bone or tooth, and the gingival tissues. This prevents the defect to be filled with soft tissue, allowing periodontal ligament tissue and bone tissue time and space to regenerate(1).
GUIDOR matrix barrier is composed of two thin layers made of a resorbable polymer. Both layers are porous – the external one with 200 x 400-micrometer pores, and the internal one with 75-micrometer pores. Soft tissue can grow through the larger pores into the space between the layers, stabilizing the membrane. The layer with smaller pores lets nutrients in the blood pass through, while blocking the growth of soft tissues into the defect. In this way, GUIDOR matrix barrier secures both the space and conditions necessary for the bone and the ligament to regenerate.
Providing a scaffold
for bone regeneration
– GUIDOR easy-graft
When periodontitis causes severe bone loss and/or the necessity to extract a tooth, GUIDOR easy-graft provides the scaffolding for bone repair (2).
- Bone cells
GUIDOR easy-graft contains 450 to 1000-micrometer calcium phosphate granules coated with a thin layer of a resorbable polymer which softens when mixed with BioLinker. This allows the granules to stick together in a moldable mass that can be directly applied from the syringe. Once the bone graft is applied into the bone defect, incoming blood washes off the BioLinker and solidifies easy-graft to make the whole scaffold stable. The blood also supplies nutrients and oxygen, and allows new bone to regrow.
- Syringe with
The regeneration of the alveolar bone is essential for keeping the tooth anchored in the jaw, or for building a solid base for implants in case of tooth loss.
Holistic oral care from prevention to regeneration
Sunstar products support oral health from preventive care, to bone regeneration-based treatments in cases where the disease has progressed severely.
Prevention of Plaque Accumulation
A regular tooth cleaning routine using G･U･M products helps minimizing plaque accumulation, contributing to healthy gums. When plaque accumulates, it can develop into gingivitis or gum disease.
Professional mechanical cleaning and antibacterial treatment
To stop periodontitis from developing, mechanical cleaning by the dentist is needed. When appropriate, the dentist may use an antibacterial treatment such as GUIDOR Periocline.
Guided Tissue Regeneration
In specific periodontal defects, regeneration can be achieved by placing GUIDOR matrix barrier, to secure space and conditions for Guided Tissue Regeneration.
Guided Bone Regeneration
Membrane (such as GUIDOR matrix barrier) and bone graft substitute (such as GUIDOR easy-graft) together enable a wider variety of Guided Bone Regeneration-based treatments.
To clear these concerns, Sunstar’s GUIDOR products are made of completely synthetic materials whose efficacy has been proven over several decades(3).
Improved periodontal regeneration around the world
Sunstar continues to develop products that ensure the acceleration of regenerative processes of periodontal tissues including bone, widening the variety of treatable cases.
With its holistic approach, Sunstar helps people around the world enjoy life with their own teeth for a longer time
Find out more
GUIDOR bioresorbable matrix barrier
GUIDOR bioresorbable matrix barrier (GUIDOR matrix barrier) is a unique range of resorbable multi-layered devices that facilitate soft tissue integration and allow Guided Tissue and Bone Regeneration. GUIDOR matrix barrier is the first and most widely studied alloplastic matrix and barrier technology available today.
GUIDOR easy-graft is a moldable, sticky bone graft substitute that can be applied directly from the syringe. When in contact with blood, GUIDOR easy-graft hardens within minutes to form a porous scaffold that perfectly fits the defect morphology thus providing excellent clot stability in the initial healing period and good bone formation.
(1) Lundgren D, Mathisen T, Gottlow J. The development of a bioresorbable barrier for guided tissue regeneration. J Swed Dent Assoc 1994; 86: 741-756.
(2) Bizenjima T, Takeuchi T, Seshima F and Saito A: Effect of poly (lactide-co-glycolide) (PLGA)-coated beta-tricalcium phosphate on the healing of rat calvarial bone defects: a comparative study with pure-phase beta-tricalcium phosphate. Clinical Oral Implants Research (2016).
(3) Yang Y, Kang Y, Sen M and Park S (2011) Bioceramics in tissue engineering. Biomaterials for Tissue Engineering Applications, Springer: 179-207.